专利内容由知识产权出版社提供
专利名称：ROTAVIRUS-LIKE PARTICLE PRODUCTION
IN PLANTS
发明人：MARC-ANDRE D AOUST,マーク－アンドル・ダ
ウー,NATHALIE LANDRY,ナタリー・ランドリー,PIERRE-OLIVIER LAVOIE,ピエール－オリヴィエ・ラボワ,ARAI MASAAKI,新井 正明,ASAHARA NAOMI,浅原 尚美,DAVID LEVIRUTENDO MUTEPFA,デイビッド・レビ・ルテンド・ムテプファ,INGA ISABEL HITZEROTH,インガ・イザベル・ヒッツェロス,RYBICKIEDWARD PETER,エドワード・ピーター・リビッキ
申请号：JP20180976申请日：20180523公开号：JP2018171058A公开日：20181108
摘要：A method of producing a virus-like particle (VLP) in a plant is provided. Themethod comprises introducing a first nucleic acid into the plant, or portion of the plant.The first nucleic acid comprising a first regulatory region active in the plant operativelylinked to a nucleotide sequence encoding one or more rotavirus structural protein forexample but not limited to rotavirus protein VP2. The nucleotide sequence may furthercomprise one or more than one amplification element and/or a compartment targetingsequence. A second nucleic acid might be introduced into the plant, or portion of the
plant. The second nucleic acid comprises a second regulatory region active in the plantand operatively linked to a nucleotide sequence encoding one or more rotavirusstructural protein, for example but not limited to rotavirus protein VP6. Optionally, athird nucleic acid and/ or fourth nucleic acid might be introduced into the plant, orportion of the plant. The third nucleic acid comprises a third regulatory region active inthe plant and operatively linked to a nucleotide sequence encoding one or morerotavirus structural protein, for example but not limited to rotavirus protein VP4. Thefourth nucleic acid comprises a fourth regulatory region active in the plant andoperatively linked to a nucleotide sequence encoding one or more rotavirus structuralprotein, for example but not limited to rotavirus protein VP7. The plant or portion of theplant is incubated under conditions that permit the expression of the nucleic acids,thereby producing the VLP.
申请人：MEDICAGO INC,メディカゴ インコーポレイテッド,MITSUBISHI TANABEPHARMA CORP,田辺三菱製薬株式会社
地址：カナダ国 ジー１ブイ ３ブイ９，ケベック，ケベック，ルート ド レグリース １０２０，スイート ６００,大阪府大阪市区道修町三丁目２番１０号
国籍：CA,JP
代理人：山尾 憲人,森本 靖,秋山 信彦
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