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Administration of macrophage targeted formulations

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专利名称:Administration of macrophage targeted

formulations of compounds which modulatecholesterol-metabolizing enzymes fortreatment of atherosclerosis

发明人:Perry M. Kim,Robert Bender申请号:US11399066申请日:20060406

公开号:US20060257466A1公开日:20061116

摘要:Macrophage targeting formulations of compounds for treating atherosclerosis,in particular compounds which modulate cholesterol-metabolizing enzymes including,but not limited to acyl CoA:cholesterol acyl transferase (ACAT) inhibitors, cholesterolester hydrolase (CEH) enhancers and combinations thereof, are provided. Methods forshort term administration of these macrophage targeting formulations to promoteregression and/or inhibit formation of atherosclerotic plaque, as well as to treat

atherosclerosis, inflammation, coronary heart disease and cardiovascular disease are alsoprovided.

申请人:Perry M. Kim,Robert Bender

地址:Inverary CA,Ottawa CA

国籍:CA,CA

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